E-cadherin Monoclonal Antibody (67A4), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA110192

Product Code. 12352213

Description

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]

E-cadherin Monoclonal antibody specifically detects E-cadherin in Human samples. It is validated for Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot.

Specifications

• Antigen: E-cadherin
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: P12830
• Gene Symbols: CDH1
• Immunogen: T-47D cells
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
• Clone: 67A4
• Conjugate: Unconjugated
• Gene: CDH1
• Gene Alias: AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 999
• Content And Storage: 4° C, do not freeze
• Form: Liquid