CD3 Mouse anti-Human, Clone: SK7, Functional Grade, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0037-81

50UG:ANTI-HUMAN CD3 FUNCTIONAL GRADE PURIFIED

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288347

Quantity Price
1 £ 95.0 / 50µg
Estimated Shipment date
from Supplier 09-12-2016
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Description and Specification

Specification

Antigen CD3
Applications Flow Cytometry
Applications Functional Assay
Clone OKT3
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Purified
Formulation aqueous buffer, no sodium azide
Gene Alias Leu-4, T3
Host Species Mouse
Isotype IgG2a
Quantity 50μg
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The OKT3 monoclonal antibody reacts with an epitope on the epsilon-subunit within the human CD3 complex. The OKT3 antibody has been reported to have potent immunosuppressive properties in vivo and has been proven effective in the treatment of renal, heart and liver allograft rejection. The CD3 subunits, gamma, delta, and epsilon chains, are required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Crosslinking of TCR initiates an intracellular biochemical pathway resulting in cellular activation and proliferation.