CD28 Monoclonal Antibody (B-23), APC, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA112260

Product Code. 11578053

Description

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.

Specifications

• Antigen: CD28
• Classification: Monoclonal
• Conjugate: APC
• Gene Accession No.: P10747
• Gene Symbols: CD28
• Immunogen: HPB-ALL T-cell line
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: B-23
• Gene: CD28
• Gene Alias: MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 940
• Content And Storage: 4° C, do not freeze
• Form: Liquid