CD279 (PD-1) Mouse anti-Human, Clone: J116, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9989-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15248857

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Description and Specification

Specification

Applications Functional Assay
Regulatory Status RUO
Formulation aqueous buffer, no sodium azide
Primary or Secondary Primary
Storage Requirements Store at 2-8°C.
Species Reactivity Human
Gene Alias PD1
Isotype IgG1
Antigen CD279 (PD-1)
Host Species Mouse
Format Purified
Cross Reactivity Human
Monoclonal or Polyclonal Monoclonal
Quantity 100μg
Conjugate Unlabeled
Concentration 1mg/mL
Clone J116

The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.