anti-CD16/FCGR3 Clone: 3G8

CD16/FCGR3 Monoclonal Ab MA5-18127 from Thermo Scientific™ specifically detects CD16/FCGR3 in Hu and Nhp samples, and it is validated for Flow Cytometry

Overview
Brand: Invitrogen

Manufacturer Part Number: MA518128

Monoclonal Antibody,CD16/FCGR3A,Alexa Fluor 647

UNSPSC: 12352203

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 15357394

Quantity Price
1 £ 254.0 / 100 tests
Estimated Shipment date
from Supplier 21-12-2016
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Description and Specification

Specification

Antigen CD16/FCGR3
Applications Flow Cytometry
Clone 3G8
Conjugate Alexa Fluor 647
Cross Reactivity Human
Cross Reactivity Non-human primate
Format Purified
Formulation 100 tests purified antibody in PBS with 0.2% BSA and 15mM sodium azide
Gene Accession No. O75015, P08637
Gene Alias FCGR3A, FCGR3B, CD16A, CD16B, Fc gamma Receptor III, Fc gamma Receptor 3, RP11-5K23.1, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA
Gene Symbols FCGR3A, FCGR3B
Host Species Mouse
Immunogen Human neutrophils
Isotype IgG1
Quantity 100 TS
Species Reactivity Human, Non-human primate
Storage Requirements DO NOT FREEZE!
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 2214, 2215

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Host Species: Mouse
Cross Reactivity: Human, Non-human primate
Isotype: IgG1
Clone: 3G8
Immunogen: Human neutrophils
Formulation: 100 tests purified antibody in PBS with 0.2% BSA and 15mM sodium azide
Synonyms: FCGR3A, FCGR3B, CD16A, CD16B, Fc gamma Receptor III, Fc gamma Receptor 3, RP11-5K23.1, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA
Uniprot Accession: O75015, P08637
Entrez GeneID: 2214, 2215
Gene Symbol: FCGR3A, FCGR3B
This product detects CD16/FCGR3 in Human and Non-human primate samples. This product has been successfully used in Flow Cytometry procedures. The immunogen is Human neutrophils.