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CD11b Rat anti-Mouse, PerCP-Cy5.5, Clone: M1/70, BD
Rat Monoclonal Antibody
£215.00 - £470.00
Specifications
Antigen | CD11b |
---|---|
Clone | M1/70 |
Concentration | 0.2mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15810789
|
BD Biosciences
561114 |
25 μg |
£215.00
Each |
Estimated Shipment: 28-05-2024 Log in to see stock. |
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15846468
|
BD Biosciences
550993 |
0.1 mg |
£470.00
Each |
Estimated Shipment: 28-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or α;M) . CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, α;Mβ;2), also known as complement receptor 3 (CR3) . Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi. Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis. Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.Specifications
CD11b | |
0.2mg/mL | |
Monoclonal | |
Rat | |
Human, Mouse | |
IgG2b κ | |
Affinity Purified | |
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain |
M1/70 | |
Flow Cytometry | |
PerCP-Cyanine5.5 | |
RUO | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.