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Cardiac Troponin I Mouse anti-Canine, Feline, Human, Porcine, Rabbit, Rat, Clone: 10B11, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA120111

Code : LE

Additional Details : CAS Number : 69-74-9 Weight : 0.01000kg

Product Code. 11573723

  • £288.00 / 200µg

Estimated Shipment date
from Supplier 01-07-2020

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Description

Description

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Specifications

Specifications

Cardiac Troponin I
Monoclonal
2 mg/mL
PBS with 0.09% sodium azide; pH 7.4
Q8MKD5, Q863B6, P19429, P45379, Q59H18, P02646, P23693, P50753, Q7TQP6
CMD2A, CMH7, MGC116817, RCM1, TNNC1, cTnI
Mouse
IgG1
200 μg
4° C
Primary
100009428, 100049696, 100533992, 100533996, 100622450, 24837, 29248, 295531, 403532, 403566, 493744, 493940, 51086, 7137, 7139
Western Blot
10B11
Unconjugated
TNNI3
Liquid
TNNI3, TNNI3K, TNNT2
Full length, human cardiac troponin 1 protein.
Protein A
RUO
Antibody
Monoclonal
Canine, Feline, Human, Porcine, Rabbit, Rat
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