BDNF Polyclonal Antibody, Invitrogen™
BDNF Antibody, PA1-18370, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: ELISA, Immunohistochemistry.
Brand: Invitrogen PA118370
Code : LD
Additional Details : Weight : 0.01000kg
DescriptionBDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to human BDNF protein aa 129-138 (HSDPARRGEL) conjugated to KLH
Formulation: 20μg purified antibody (1mg/mL) and no preservative
Synonyms: Brain-derived neurotrophic factor, Abrineurin
Uniprot Accession: P21237, P23363, P23560
Entrez GeneID: 12064, 24225, 627
Gene Symbol: BDNF
The immunogenic sequence is highly conserved among most mammalian species. This antibody exhibits less than 0.1% cross reactivity with mouse NGF, recombinant human NT3 and NT4/5 by dot blot analysis. Reconstitute with 20 ul of distilled water.
|P21237, P23363, P23560|
|Brain-derived neurotrophic factor, Abrineurin|
|avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.|
|20μg purified antibody (1mg/mL) and no preservative|
|A synthetic peptide corresponding to human BDNF protein aa 129-138 (HSDPARRGEL) conjugated to KLH|
|12064, 24225, 627|