anti-BDNF Polyclonal, Thermo Scientific™

BDNF Polyclonal Ab PA1-18357 from Thermo Scientific™ specifically detects BDNF in Hu, Ms and Rt samples, and it is validated for ELISA, IHC, Inhibition Assays and WB

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-18370

BDNF

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11582012

Quantity Price
1 £ 293.0 / 20µg
Estimated Shipment date
from Supplier 13-01-2017
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Description and Specification

Specification

Antigen BDNF
Applications Enzyme Linked Immunosorbent Assay
Applications Immunohistochemistry
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Formulation 20μg purified antibody (1mg/mL) and no preservative
Gene Accession No. P21237, P23363, P23560
Gene Alias Brain-derived neurotrophic factor, Abrineurin
Gene Symbols BDNF
Host Species Rabbit
Immunogen A synthetic peptide corresponding to human BDNF protein aa 129-138 (HSDPARRGEL) conjugated to KLH
Isotype IgG
Quantity 20μg
Species Reactivity Human, Mouse, Rat
Storage Requirements avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 12064, 24225, 627

BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: A synthetic peptide corresponding to human BDNF protein aa 129-138 (HSDPARRGEL) conjugated to KLH
Formulation: 20μg purified antibody (1mg/mL) and no preservative
Synonyms: Brain-derived neurotrophic factor, Abrineurin
Uniprot Accession: P21237, P23363, P23560
Entrez GeneID: 12064, 24225, 627
Gene Symbol: BDNF
The immunogenic sequence is highly conserved among most mammalian species. This antibody exhibits less than 0.1% cross reactivity with mouse NGF, recombinant human NT3 and NT4/5 by dot blot analysis. Reconstitute with 20 ul of distilled water.