Acinus Polyclonal Antibody, Invitrogen™

Acinus Antibody, PA1-12497, from Invitrogen™. Species Reactivity: Human; Applications: Western Blot.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-12497

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11525982

Quantity Price
1 £ 292.0 / 100µg
Estimated Shipment date
from Supplier 20-04-2017
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Description and Specification

Specification

Gene ID (Entrez) 22985
Formulation 100μg purified antibody (0.5mg/mL) in PBS and 0.02% sodium azide
Immunogen 602-614 of human AcinusS' or 571-583 of human AcinusS
Cross Reactivity Human
Antigen Acinus
Storage Requirements Avoid Freeze/Thaw Cycles
Isotype IgG
Primary or Secondary Primary
Gene Accession No. Q9UKV3
Format Purified
Host Species Rabbit
Conjugate Unlabeled
Species Reactivity Human
Monoclonal or Polyclonal Polyclonal
Quantity 100μg
Gene Alias Apoptotic chromatin condensation inducer in the nucleus
Applications Western Blotting
Gene Symbols ACIN1

Chromatin condensation and nuclear fragmentation (CCNF)is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: Synthetic peptide (SRSTPVRDRGGRR) corresponding to aa 1329-1341 of human AcinusL, 602-614 of human AcinusS' or 571-583 of human AcinusS
Formulation: 100μg purified antibody (0.5mg/mL) in PBS and 0.02% sodium azide
Synonyms: Apoptotic chromatin condensation inducer in the nucleus
Uniprot Accession: Q9UKV3
Entrez GeneID: 22985
Gene Symbol: ACIN1
A suggested positive control for this product is K562 cell lysate.