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Invitrogen™ eBioscience™ Human TGF beta 3, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand:  Invitrogen™ 34-8734-85

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15588826

  • £3013.64 / 500µg


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Description

Description

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.

The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
Specifications

Specifications

Functional Assays
25.0kDa
SDS-PAGE and HPLC
500μg
Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.
E. coli (amino acids Ala 301 - Ser412; Accession # NP_003230.1)
Transforming Growth Factor beta 3
Recombinant Protein, Carrier-Free
Human
Lyophilized from 0.1% TFA.
TGF beta 3
>98%
E. coli
RUO
Less than 0.1ng/μg cytokine as determined by the LAL assay
The ED50 of this protein, as measured by inhibition of IL-4-induced proliferation of mouse HT-2 cells, is less than or equal to 0.05ng/mL, which corresponds to a specific activity of greater than 2 x 107 Units/mg.
Unlabeled
Yes
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