eBioscience™ Human TGF beta 3, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand: Affymetrix eBioscience

Manufacturer Part Number: 34-8734-85

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Product Code. 15588826

Quantity Price
1 £ 3013.64 / 500µg
Estimated Shipment date
from Supplier 31-05-2017
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Description and Specification


For Use With (Application) Functional Assays
Name TGF beta 3
Quantity 500μg
Regulatory Status RUO
Formulation Lyophilized from 0.1% TFA.
Biological Activity The ED50 of this protein, as measured by inhibition of IL-4-induced proliferation of mouse HT-2 cells, is less than or equal to 0.05ng/mL, which corresponds to a specific activity of greater than 2 x 107 Units/mg.
Source E. coli
Molecular Weight 25.0kDa
Product Type Recombinant Protein, Carrier-Free
Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.
Purity >98%
Cross Reactivity Human
Purification Method SDS-PAGE and HPLC
Gene Symbol Transforming Growth Factor beta 3
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay
Recombinant Yes
Structural Form E. coli (amino acids Ala 301 - Ser412; Accession # NP_003230.1)
Conjugate Unlabeled

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.

The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.