eBioscience™ Human TGF beta 3, Recombinant Protein, Carrier-Free
Human Recombinant Protein
Brand: Affymetrix eBioscience 34-8734-85
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionTransforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.
The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
|SDS-PAGE and HPLC|
|Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.|
|E. coli (amino acids Ala 301 - Ser412; Accession # NP_003230.1)|
|Transforming Growth Factor beta 3|
|Recombinant Protein, Carrier-Free|
|Lyophilized from 0.1% TFA.|
|TGF beta 3|
|Less than 0.1ng/μg cytokine as determined by the LAL assay|
|The ED50 of this protein, as measured by inhibition of IL-4-induced proliferation of mouse HT-2 cells, is less than or equal to 0.05ng/mL, which corresponds to a specific activity of greater than 2 x 107 Units/mg.|