eBioscience™ Human IL-17E (IL-25), Recombinant Protein, Carrier-Free

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 34-8736-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15508836

Quantity Price
1 £ 146.13 / 25µg
Estimated Shipment date
from Supplier 31-05-2017
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Description and Specification

Specification

Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.
Structural Form E. coli (amino acids Met17-Gly; Accession # AAI04930.1)
Conjugate Unlabeled
Purification Method SDS-PAGE and HPLC
Formulation Lyophilized from 10mM acetic acid
Quantity 25μg
Gene Symbol Interleukin-17E, Interleukin-25
For Use With (Application) Functional Assays
Regulatory Status RUO
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay
Source E. coli
Recombinant Yes
Name IL-17E (IL-25)
Molecular Weight 33.8kDa disulfide-linked homodimer of two 145 aa polypeptide chains
Cross Reactivity Human
Purity >98%
Biological Activity This protein (10-100 ng) can to induce IL-8 secretion from normal human peripheral blood cells.
Product Type Recombinant Protein, Carrier-Free

IL-17E, or IL-25, was first identified as an IL-17 family member on the basis of sequence homology. It was originally believed to be a Th2 cytokine based on the detection of mRNA transcripts in polarized Th2 cells, but expression was later observed in epithelial cells, eosinophils, and mast cells. Studies have confirmed the role of IL-17E as a potent inducer of type 2 immune responses. IL-17E signaling induces the differentiation of CD4+ T cells towards the Th2 lineage and upregulates expression of Th2 cytokines such as IL-4, IL-5, and IL-13. Administration of IL-17E also promotes symptoms of allergic asthma, such as eosinophil infiltration, airway hyperreactivity, and high circulating levels of IgE. IL-17E binds to IL-17BR, a receptor shared with IL-17B, and activates NF-kappa B pathways.