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eBioscience™ Human IL-17E (IL-25), Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand:  Affymetrix eBioscience 34-8736-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15508836

  • £146.13 / 25µg


EU Stock 1
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Description

Description

IL-17E, or IL-25, was first identified as an IL-17 family member on the basis of sequence homology. It was originally believed to be a Th2 cytokine based on the detection of mRNA transcripts in polarized Th2 cells, but expression was later observed in epithelial cells, eosinophils, and mast cells. Studies have confirmed the role of IL-17E as a potent inducer of type 2 immune responses. IL-17E signaling induces the differentiation of CD4+ T cells towards the Th2 lineage and upregulates expression of Th2 cytokines such as IL-4, IL-5, and IL-13. Administration of IL-17E also promotes symptoms of allergic asthma, such as eosinophil infiltration, airway hyperreactivity, and high circulating levels of IgE. IL-17E binds to IL-17BR, a receptor shared with IL-17B, and activates NF-kappa B pathways.
Specifications

Specifications

Functional Assays
33.8kDa disulfide-linked homodimer of two 145 aa polypeptide chains
SDS-PAGE and HPLC
25μg
Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.
E. coli (amino acids Met17-Gly; Accession # AAI04930.1)
Interleukin-17E, Interleukin-25
Recombinant Protein, Carrier-Free
Human
Lyophilized from 10mM acetic acid
IL-17E (IL-25)
>98%
E. coli
RUO
Less than 0.1ng/μg cytokine as determined by the LAL assay
This protein (10-100 ng) can to induce IL-8 secretion from normal human peripheral blood cells.
Unlabeled
Yes