Ankyrin 1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA563372

Product Code. 15701152

Description

Immunogen sequence: FVLVSDKHRM SFPETVDEIL DVSEDEGEEL ISFKAERRDS RDVDEEKELL DFVPKLDQVV ESPAIPRIPC AMPETVVIRS EEQEQASKEY DEDSLIPSSP Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 83%.

Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.

Specifications

• Antigen: Ankyrin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANK1
• Gene Alias: ANK; ANK1; ANK-1; ANK-1; erythrocyte skeletal protein; ankyrin 1; ankyrin 1, erythrocytic; ankyrin 1, erythroid; ankyrin-1; Ankyrin-R; erythrocyte ankyrin; nb; normoblastic anemia; pale; rCG_43073; SPH1; SPH2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 286
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.6 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P16157
• Gene Symbols: ANK1
• Immunogen: Recombinant protein corresponding to Human Ankyrin 1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only