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alpha beta TCR Mouse anti-Human, FITC, Clone: WT31, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-9955-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15586646

  • £48.31 / 25 tests


Estimated Shipment date
from Supplier 21-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

This WT31 monoclonal antibody recognizes the human alpha beta T cell receptor (TCR) complexed with the CD3 epsilon chain. Composed of a 44kDa alpha and a 37kDa beta chain, TCR specificity is typically determined by V alpha, J alpha, V beta, D beta, and J beta gene rearrangement. The TCR is often associated with the CD3 complex, which is composed of at least five polypeptides. The TCR/CD3 complex recognizes and binds to major histocompatibility complex-bound antigen presented by antigen presenting cells such as B cells, dendritic cells, and macrophages. These events lead to T cell activation, resulting in cellular signaling and cytokine production.

The WT31 monoclonal antibody has been reported to induce proliferation of resting T cells, as well as inhibit cytotoxic T cell activity. In addition, some antibodies against CD3 partially inhibit alpha beta TCR antibody staining using WT31; clone SK7 (anti-human CD3) is recommended for use in two-color experiments.
Specifications

Specifications

alpha beta TCR
WT31
FITC
Conjugated
IgG1
RUO
Primary
Human
Flow Cytometry
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal