Thermo Scientific Chemicals Aldosterone, 98%

Description

Aldosterone, CAS # 52-39-1, is a hormone secreted by the adrenal cortex, which regulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Aldosterone is a pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland by the action of aldosterone synthase (CYP11B2)

It modulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

Applications

Aldosterone binds to mineralocorticoid receptors (MR; NR3C2) and MR-aldosterone complexes regulating the expression of genes involved in the retention of sodium, secretion of potassium, and water reabsorption, resulting in an increase in the blood pressure

In vitro, it has been involved with the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes

Aldosterone has been used in combination with salt to induce renal injury in mice

It is used to stimulate primary liver sinusoidal endothelial cells

Specifications

• CAS Min %: 97.5
• CAS Max %: 100.0
• Color: White
• Loss on Drying: 6.0% max. (105°C, 3 hrs)
• Infrared Spectrum: Authentic
• Assay Percent Range: 98%
• Packaging: Glass bottle
• Quantity: 5 mg
• Beilstein: 08, IV, 3491
• Merck Index: 15, 218
• Specific Rotation: +150° to +162° (20°C, 589nm) (c=0.1, CHCl3)
• Formula Weight: 360.45
• Percent Purity: ≥97.5% (HPLC)
• Physical Form: Crystalline Powder
• Chemical Name or Material: Aldosterone, 98%

RUO – Research Use Only