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AIRE Monoclonal Antibody (5H12), eFluor™ 660, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-5934-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15529996

  • £433.00 / 100µg
Estimated Shipment: 07-05-2024
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Description

Description

Description: This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58-kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation. The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2. Applications Reported: This 5H12 antibody has been reported for use in intracellular flow cytometric analysis and immunohistochemical staining of frozen tissue sections. Applications Tested: This 5H12 antibody has been tested by immunohistochemistry on frozen 5-week-old mouse thymus and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. eFluor™ 660 is a replacement for Alexa Fluor™ 647. eFluor™ 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

AIRE Monoclonal antibody specifically detects AIRE in Mouse samples. It is validated for Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen).
Specifications

Specifications

AIRE
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9Z0E3
Aire
Affinity chromatography
RUO
11634
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen)
5H12
eFluor 660
Aire
Aire; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1
Rat
100 μg
Primary
Mouse
Antibody
IgG2c κ
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For Research Use Only.