AIRE Rat anti-Mouse, Alexa Fluor 488, Clone: 5H12, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-5934-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15332050

Quantity Price
1 £ 84.99 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Gene Alias Autoimmune Regulator
Species Reactivity Mouse
Primary or Secondary Primary
Conjugate Alexa Fluor 488
Isotype IgG2c
Quantity 25μg
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen AIRE
Host Species Rat
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 5H12

This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation.

The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2.