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AIRE Rat anti-Human, Clone: TM-724, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9534-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15507606

  • £111.78 / 100µg


Estimated Shipment date
from Supplier 03-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This TM-724 monoclonal antibody reacts with human Autoimmune Regulator (AIRE). This 58kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). AIRE mRNA in the periphery has been observed in the lymph node, fetal liver, and intestines. Furthermore expression has been observed in dendritic cells, epithelial cells and PBMCs. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation. As a result of alternative splicing, three isoforms have been reported. The conditions autoimmune–polyendocrinopathy–candiasis–ectodermal–dystrophy (APECED) and autoimmune polyglandular syndrome type 1 (APS-1) arise from mutations in the human AIRE gene.

The TM-724 antibody is predicted to recognize all three isoforms of human AIRE (AIRE-1, AIRE-2, AIRE-3).
Description & Specifications

Specifications

AIRE
TM-724
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
100μg
Store at 2-8°C.
Monoclonal
Immunohistochemistry (Frozen)
0.5mg/mL
Purified
Autoimmune Regulator
IgG2a
RUO
Primary
Human