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Aiolos Mouse anti-Mouse, Clone: 8B2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5789-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15297467

  • £195.05 / 100µg


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For Research Use Only.


Specifications

Description

This 8B2 monoclonal antibody reacts with mouse Aiolos, a 58kDa member of the Ikaros family of zinc finger transcription factors. Expression of Aiolos is restricted to the lymphoid lineage, with B cells exhibiting the highest levels of expression, followed by NK and T cells. Studies demonstrate that Aiolos forms homodimers or heterodimerizes with Ikaros proteins. Moreover, Aiolos exhibits tyrosine phosphorylation and nuclear localization in response to IL-2 stimulation in T cells. Aiolos plays a role in IL-2-mediated anti-apoptosis by controlling Bcl-2 expression. Finally, Aiolos is involved in B cell development, with upregulation of this transcription factor observed at the pre-BI to pre-BII transition in response to pre-B cell receptor signaling.
Description & Specifications

Specifications

Aiolos
8B2
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
Purified
IKZF3
IgG1
RUO
Primary
Murine