Aiolos Mouse anti-Mouse, Clone: 8B2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5789-80

25UG:ANTI-MOUSE AIOLOS PURIFIED 25 UG

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15287467

Quantity Price
1 £ 78.88 / 25µg
Estimated Shipment date
from Supplier 27-03-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Conjugate Unlabeled
Antigen Aiolos
Format Purified
Gene Alias IKZF3
Host Species Mouse
Applications Western Blotting
Isotype IgG1
Quantity 25μg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Clone 8B2
Concentration 0.5mg/mL

This 8B2 monoclonal antibody reacts with mouse Aiolos, a 58kDa member of the Ikaros family of zinc finger transcription factors. Expression of Aiolos is restricted to the lymphoid lineage, with B cells exhibiting the highest levels of expression, followed by NK and T cells. Studies demonstrate that Aiolos forms homodimers or heterodimerizes with Ikaros proteins. Moreover, Aiolos exhibits tyrosine phosphorylation and nuclear localization in response to IL-2 stimulation in T cells. Aiolos plays a role in IL-2-mediated anti-apoptosis by controlling Bcl-2 expression. Finally, Aiolos is involved in B cell development, with upregulation of this transcription factor observed at the pre-BI to pre-BII transition in response to pre-B cell receptor signaling.