Aiolos Mouse anti-Mouse, Clone: 8B2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5789-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15287467

Quantity Price
1 £ 78.88 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Conjugate Unlabeled
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 8B2
Applications Western Blotting
Host Species Mouse
Isotype IgG1
Antigen Aiolos
Species Reactivity Mouse
Gene Alias IKZF3
Quantity 25μg
Concentration 0.5mg/mL
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C.
Format Purified
Regulatory Status RUO

This 8B2 monoclonal antibody reacts with mouse Aiolos, a 58kDa member of the Ikaros family of zinc finger transcription factors. Expression of Aiolos is restricted to the lymphoid lineage, with B cells exhibiting the highest levels of expression, followed by NK and T cells. Studies demonstrate that Aiolos forms homodimers or heterodimerizes with Ikaros proteins. Moreover, Aiolos exhibits tyrosine phosphorylation and nuclear localization in response to IL-2 stimulation in T cells. Aiolos plays a role in IL-2-mediated anti-apoptosis by controlling Bcl-2 expression. Finally, Aiolos is involved in B cell development, with upregulation of this transcription factor observed at the pre-BI to pre-BII transition in response to pre-B cell receptor signaling.