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AHR Monoclonal Antibody (4MEJJ), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£138.00 - £325.00
Specifications
Antigen | AHR |
---|---|
Clone | 4MEJJ |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15550227
|
Affymetrix eBioscience
53-5925-80 |
25 μg |
£138.00
25µg |
Estimated Shipment: 26-04-2024 Log in to see stock. |
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15560227
|
Affymetrix eBioscience
53-5925-82 |
100 μg |
£325.00
100µg |
Estimated Shipment: 24-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Description: This 4MEJJ monoclonal antibody recognizes mouse aryl hydrocarbon receptor (AHR). The AHR is a ligand-activated transcription factor that mediates the toxic effects of a diverse group of environmental contamits, most notably aryl hydrocarbons such as polychlorinated biphenyls (PCB) and tetrachlorodibenzo-p-dioxin (TCDD). The AHR has also been shown to bind to a number of naturally occurring compounds found in fruits and vegetables as well as compounds generated through normal cellular metabolism. AHR is localized in the cytoplasm in a complex that includes HSP90, p23, and XAP2/AIP/ARA9. Upon ligand-binding, AHR translocates to the nucleus and binds with aryl hydrocarbon receptor nuclear translocator (ARNT), and this complex binds to the consensus DNA sequence, GCGTG, found in the promoter/enhancer regions of many genes such as CYP1A1. The AHR is expressed in many cell types, with highest expression levels found in liver. The AHR has been shown to play a role in the regulation/differentiation of Treg and Th17 cells. The 4MEJJ monoclonal antibody has been found to recognize the b-1, b-2 and d alleles of mouse AHR but does not crossreact with human AHR. Applications Reported: This 4MEJJ antibody has been reported for use in intracellular staining followed by flow cytometric analysis.
AHR Monoclonal antibody specifically detects AHR in Mouse samples. It is validated for Flow Cytometry.Specifications
AHR | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
Ah; Ah receptor; Ahh; Ahr; Ahre; AH-receptor; aromatic hydrocarbon receptor; aryl hydrocarbon receptor; aryl-hydrocarbon receptor; bHLHe76; Class E basic helix-loop-helix protein 76; dioxin receptor; In | |
AHR | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
4MEJJ | |
Flow Cytometry | |
Alexa Fluor 488 | |
Rat | |
Mouse | |
P30561 | |
11622 | |
E. coli derived, His-tagged AHR (aa 443-805) | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
AHR |
For Research Use Only.