AHR Mouse anti-Human, eFluor 660, Clone: FF3399, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-9854-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15540147

Quantity Price
1 £ 107.01 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Isotype IgG2b
Antigen AHR
Gene Alias Aryl hydrocarbon receptor
Quantity 25 tests
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.5μg)/test
Primary or Secondary Primary
Format Conjugated
Applications Flow Cytometry (Intracellular Staining)
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Clone FF3399
Regulatory Status RUO
Species Reactivity Human
Conjugate eFluor 660
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The FF3399 monoclonal antibody recognizes human aryl hydrocarbon receptor (AHR). The AHR is a ligand-activated transcription factor that mediates the toxic effects of a diverse group of environmental contaminants, most notably aryl hydrocarbons such as polychlorinated biphenyls (PCB) and tetrachlorodibenzo-p-dioxin (TCDD). The AHR has also been shown to bind to a number of naturally occurring compounds found in fruits and vegetables as well as compounds generated through normal cellular metabolism. AHR is localized in the cytoplasm in a complex that includes HSP90, p23, and XAP2/AIP/ARA9. Upon ligand-binding, AHR translocates to the nucleus and binds with aryl hydrocarbon receptor nuclear translocator (ARNT), and this complex binds to the consensus DNA sequence, GCGTG, found in the promoter/enhancer regions of many genes such as CYP1A1. The AHR is expressed in many cell types, with highest expression levels found in liver. The AHR has been shown to play a role in the regulation/differentiation of Treg and Th17 cells.