Activation-Induced Cytidine Deaminase (AID) Rat anti-Human, Mouse, Biotin, Clone: mAID-2, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-5959-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15567346

Quantity Price
1 £ 231.74 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Clone mAID-2
Isotype IgG2a
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 100μg
Antigen Activation-Induced Cytidine Deaminase (AID)
Format Conjugated
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Applications Western Blotting
Conjugate Biotin
Regulatory Status RUO
Gene Alias aicda
Species Reactivity Human, Mouse
Host Species Rat
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze.
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL

The monoclonal mAID-2 recognizes human and mouse AID (gene AICDA) also known as Activation-Induced Cytidine Deaminase. AID is a 24kDa RNA-editing enzyme that converts cytosine into uracil. It plays a critical role during B cell development, specifically in somatic hypermutation (SHM) and immunoglobulin class switch recombination (CSR). Changes in levels of AID expression typically present with disease. For example, mutations in AID are found in Hyper-IgM Syndrome (type 2), a disease form without opportunistic infections, while overexpression correlates with poor prognosis in chronic lymphocytic leukemia/small lymphocytic lymphoma.

AID is expressed mainly by activated mature B cells such as mature germinal centre (GC) B cells but also in intermediate GC cells (defined as IgD+CD38-CD23-CD71+). In addition to hematopoietic cells, AID is expressed in primary human hepatocellular carcinomas, helicobacter infected gastric epithelial cells, oocytes and embryonic stem cells although it role in these cells is not well understood. Because AID contains an NLS (nuclear localization signal), expression can be found both in the nucleus as well as in the cytoplasm.