Alfa Aesar™ Actinomycin D


Overview
Brand: Alfa Aesar™

Manufacturer Part Number: J60148-LB0

5MG Actinomycin D

UNSPSC: 12352200

Code: NEW

Additional Details:
Additional Details: CAS Number: 50-76-0 Weight: 0.00005kg


Quantity 5mg

Product Code. 15452969

Quantity Price
1 £ 71.76 / 5mg
Estimated Shipment date
from Supplier 07-12-2016
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Description and Specification

Chemical Identifiers

Chemical Name or Material Actinomycin D
CAS 50-76-0
Formula Weight 1255.40g/mol
MDL Number MFCD00005033
UN Number UN3462
Beilstein 605235
Merck Index 14,2800
Synonym Dactinomycin; Actinomycin C1

Specification

Color Orange to red
Melting Point 251 to 253°C
Quantity 5mg
Chemical Name or Material Actinomycin D
CAS 50-76-0
Physical Form Powder
Formula Weight 1255.40g/mol
MDL Number MFCD00005033
UN Number UN3462
Beilstein 605235
Merck Index 14,2800
Synonym Dactinomycin; Actinomycin C1
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H300-H360-H351
Fatal if swallowed.
May damage fertility or the unborn child.
Suspected of causing cancer.
Health Hazard 3 GHS P Statement
P281-P301+P310-P308+P313-P321-P405-P501a
Use personal protective equipment as required.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF exposed or concerned: Get medical advice/attention.
Specific treatment (see label).
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Storage Note 1 -30° to -10°C
DOT Information Transport Hazard Class: 6.1; Packaging Group: II; Proper Shipping Name: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S.
RTECS Number AU1575000

Applications
Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells.

Solubility
It is soluble ino 50 mM in DMSO.

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Safety and Handling

Danger

GHS H Statement
H300-H360-H351
Fatal if swallowed.
May damage fertility or the unborn child.
Suspected of causing cancer.

GHS P Statement
P281-P301+P310-P308+P313-P321-P405-P501a
Use personal protective equipment as required.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF exposed or concerned: Get medical advice/attention.
Specific treatment (see label).
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

-30° to -10°C