Alfa Aesar™ Actinomycin D


Overview
Brand: Alfa Aesar™

Manufacturer Part Number: J60148.#0

UNSPSC: 12352200

Code: NEW

Additional Details:
Additional Details: CAS Number: 50-76-0 Weight: 0.00005kg


Quantity 5mg

Product Code. 15452969

Quantity Price
1 £ 71.76 / 5mg
Estimated Shipment date
from Supplier 15-05-2017
Add to basket


Description and Specification

Chemical Identifiers

Chemical Name or Material Actinomycin D
CAS 50-76-0
Formula Weight 1255.4
MDL Number MFCD00005033
UN Number UN3462
Beilstein 605235
Merck Index 14,2800
Synonym Dactinomycin; Actinomycin C1

Specification

Formula Weight 1255.4
Melting Point 251° to 253°C
Health Hazard 3 GHS P Statement
P281-P301+P310-P308+P313-P321-P405-P501a
Use personal protective equipment as required.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF exposed or concerned: Get medical advice/attention.
Specific treatment (see label).
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Color Orange to red
RTECS Number AU1575000
Merck Index 14,2800
Health Hazard 2 GHS H Statement
H300-H360-H351
Fatal if swallowed.
May damage fertility or the unborn child.
Suspected of causing cancer.
Chemical Name or Material Actinomycin D
DOT Information Transport Hazard Class: 6.1; Packaging Group: II; Proper Shipping Name: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S.
MDL Number MFCD00005033
Synonym Dactinomycin; Actinomycin C1
UN Number UN3462
CAS 50-76-0
Physical Form Powder
Storage Note 1 -30° to -10°C
Health Hazard 1 Danger
Beilstein 605235
Quantity 5mg

Applications
Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells.

Solubility
It is soluble ino 50 mM in DMSO.

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Documentation

Technical documents

Safety and Handling

Danger

GHS H Statement
H300-H360-H351
Fatal if swallowed.
May damage fertility or the unborn child.
Suspected of causing cancer.

GHS P Statement
P281-P301+P310-P308+P313-P321-P405-P501a
Use personal protective equipment as required.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF exposed or concerned: Get medical advice/attention.
Specific treatment (see label).
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

-30° to -10°C