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ACT1, clone: 9ACT12, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-4040-82

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15217357

  • £142.50 / 100µg


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Description

Description

Description: The monoclonal antibody 9ACT12 reacts with human Act1 (NF-kappaB activator 1), also known as CIKS (a connection to IkB kinase and stress-activated kinase). Originally cloned for its ability to activate NF-kappaB and its direct interaction with IKKgamma, Act1 has been subsequently shown to play several roles in immunity. In B cells, it is a negative regulator of CD40 and BAFFR signaling affecting reduced survival. This regulation is through direct interaction of Act1 with CD40 or BAFFR and TRAF3. In addition, Act1 is involved in IL-17R signaling. It interacts with IL-17RA through the homotypic SEFIR interaction domain and is critical for downstream NF-kappaB- and C/EBP-mediated inflammatory responses.Applications Reported: This 9ACT12 antibody has been reported for use in immunoblotting (WB).Applications Tested: This 9ACT12 antibody has been tested by immunoblot of human peripheral blood cell lysates. This can be used at less than or equal to 1-5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

ACT1
9ACT12
Unconjugated
Purified
Rat
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Nuclear Factor kappa B Activator 1, TRAF3 interacting protein 2, TRAF3IP2, CIKS
IgG1
RUO
Primary
Human
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