ACT1 Rat anti-Human, Clone: 9ACT12, eBioscience™

Rat Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-4040-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg

Disclaimers: For Research Use Only.

Product Code. 15207357

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification


Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Applications Western Blotting
Conjugate Unlabeled
Isotype IgG1
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Gene Alias Nuclear Factor kappa B Activator 1, TRAF3 interacting protein 2, TRAF3IP2, CIKS
Host Species Rat
Format Purified
Antigen ACT1
Clone 9ACT12
Concentration 0.5mg/mL
Quantity 25μg

The monoclonal antibody 9ACT12 reacts with human Act1 (NF-κB activator 1), also known as CIKS (a connection to IkB kinase and stress-activated kinase). Originally cloned for its ability to activate NF-κB and its direct interaction with IKKγ, Act1 has been subsequently shown to play several roles in immunity. In B cells, it is a negative regulator of CD40 and BAFFR signaling affecting reduced survival. This regulation is through direct interaction of Act1 with CD40 or BAFFR and TRAF3. In addition, Act1 is involved in IL-17R signaling. It interacts with IL-17RA through the homotypic SEFIR interaction domain and is critical for downstream NF-κB- and C/EBP-mediated inflammatory responses.