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(-)-[3R,4S]-Chromanol 293B, Tocris Bioscience™

IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

Brand:  Tocris (Bio-Techne) 147510

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13439563

  • £178.20 / 10mg

Estimated Shipment
09-07-2019

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Description

Description

Enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).

Racemate also available.

Specifications

Chemical Identifiers

163163-24-4
324.395
chromanol 293b, n-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-1-benzopyran-4-yl-n-methylethanesulfonamide, ethanesulfonic acid 6-cyano-3-hydroxy-2,2-dimethyl-chroman-4-yl-methyl-amide, 6-cyano-4-n-ethylsulfonyl-n-methylamino-3-hydroxy-2,2-dimethyl chromane, n-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl-n-methylethanesulfonamide
CHEBI:34637
CCS(=O)(=O)N(C)C1C(C(OC2=C1C=C(C=C2)C#N)(C)C)O
C15H20N2O4S
HVSJHHXUORMCGK-UONOGXRCSA-N
121846
N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide

Specifications

(-)-[3R, 4S]-Chromanol 293B
163163-24-4
chromanol 293b, n-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-1-benzopyran-4-yl-n-methylethanesulfonamide, ethanesulfonic acid 6-cyano-3-hydroxy-2,2-dimethyl-chroman-4-yl-methyl-amide, 6-cyano-4-n-ethylsulfonyl-n-methylamino-3-hydroxy-2,2-dimethyl chromane, n-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl-n-methylethanesulfonamide
CCS(=O)(=O)N(C)C1C(C(OC2=C1C=C(C=C2)C#N)(C)C)O
324.395
CHEBI:34637
>99%
10mg
C15H20N2O4S
HVSJHHXUORMCGK-UONOGXRCSA-N
N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide
121846
324.39
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