3G11 Sialoganglioside Antigen Monoclonal Antibody (eBio3G11 (SM3G11, 3G11)), eFluor™ 660, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-5443-80

Product Code. 15519976

Description

The 3G11 sialylated carbohydrate antigen was found to be expressed by thymoyctes and peripheral T cells, but not by B cells, myeloid cells or erythrocytes. 3G11 is expressed at higher levels on CD4+ T cells than on CD8+ T cells, however expression on both of these subsets decreases with advancing age. In thymus, 3G11 is expressed on approximately 20% of total thymocytes. 3G11 has also been used as a marker to distinguish naive and memory T cells, as 3G11 is irreversibly down-regulated upon activation of CD4+ T cells. 3G11 antibodies can be used to block binding of antibodies to CD3 epsilon, suggesting close proximity of these two proteins. Recently, it has been demonstrated that loss of 3G11 expression in experimental autoimmune encephalomyelitis (EAE) is associated with an anergic, regulatory T phenotype. Purified 3G11- T cells were able to suppress proliferation and cytokine production of 3G11+ T cells, and part of this effect was due to the secretion of IL-10.

3G11 Sialoganglioside Antigen Monoclonal antibody specifically detects 3G11 Sialoganglioside Antigen in Mouse, Rat samples. It is validated for Flow Cytometry.

Specifications

• Antigen: 3G11 Sialoganglioside Antigen
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Host Species: Mouse
• Quantity: 25 μg
• Primary or Secondary: Primary
• Content And Storage: 4° C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: eBio3G11 (SM3G11, 3G11), 3G11)
• Conjugate: eFluor 660
• Gene Alias: 3G11 antigen
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgM κ

For Research Use Only.