CAS RN 1234015-54-3

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Prexasertib dihydrochloride, MedChemExpress

MedChemExpress Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of 50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity.

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Specifications

Molecular Weight (g/mol)	438.31
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Prexasertib dihydrochloride
Grade	Research
SMILES	NCCCOC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2.[H]Cl.[H]Cl
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.0%
CAS	1234015-54-3
Solubility Information	DMSO : 8 mg/mL (18.25 mM; Need ultrasonic) ∣H2O : 1 mg/mL (2.28 mM; ultrasonic and warming and heat to 80°C)
Synonym	LY2606368 dihydrochloride
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₁₈H₂₁Cl₂N₇O₂
Formula Weight	438.31

CAS RN 1234015-54-3

CAS RN 1234015-54-3

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